Laboratory website: chesslerlab.ucsd.edu
Dr. Chessler received his MD and Ph.D. degrees from the University of Washington. After completion of the Medical Scientist Training Program, he stayed on at the University of Washington for a residency in Internal Medicine followed by a combined clinical and research endocrinology fellowship. Dr. Chessler then remained three years at UW as a junior faculty member before joining the Department of Medicine at UCSD as an Assistant Professor. In addition to his research work related to pancreatic islet biology and diabetes, Dr. Chessler has occasional patient care and clinical teaching responsibilities in Endocrinology and Metabolism within the UCSD healthcare system. He is also affiliated with UCSD’s Biomedical Sciences (BMS) Graduate Program.
Dr. Chessler is investigating the cellular and molecular biology of insulin-producing pancreatic islets, and the process that controls insulin secretion. He is also researching cellular events that cause islet damage and dysfunction in diabetes.
Suckow, A.T., Sweet, I.R., Van Yserloo, B., Rutledge, E. A., Hall, T. R., Waldrop, M., and Chessler, S.D. (2006). Identification and characterization of a novel isoform of the vesicular GABA transporter with glucose-regulated expression in rat islet. J. Mol. Endo., 36, 187-199.
Waldrop, M.A., Suckow, A.T., Hall, T.R., Hampe, C.S., Marcovina, S.M. and Chessler, S.D. (2006). A highly sensitive immunoassay resistant to autoantibody interference for detection of the diabetes-associated autoantigen GAD65 in blood and other biological samples. Diabetes Technol. Ther., 8, 207-218.
Waldrop, M.A., Suckow, A.T., Marcovina, S.M. and Chessler, S.D. (2007). Release of GAD65 into the Circulation by Injured Pancreatic Islet β Cells. Endocrinology, 148, 4572-4578. [see also commentary on this manuscript: Hincke, S.A. (2007). Finding GAD: early detection of beta-cell injury. Endocrinology 148, 4568-4571.]
Suckow, A.T., Comoletti, D., Waldrop, M., Mosedale, M., Egodage, S., Taylor, P. and Chessler, S.D. (2008). Expression of neurexin, neuroligin and their cytoplasmic binding partners in the pancreatic b-cells and the involvement of neuroligin in insulin secretion. Endocrinology, 149, 6006-17.