Dr. C.C. King joined UCSD’s Department of Pediatrics as an associate research scientist in 2003 after doing his postdoctoral work at UCSD and The Scripps Research Institute in La Jolla. After earning his PhD degree from the University of Tennessee, Memphis, Dr. King’s work focused on the role of enzymes called protein kinases in insulin signaling, and techniques for separating different types of molecules, based on their patterns of movement in an electrical field.
Dr. King’s research is primarily focused on insulin signal transduction pathways and he is an expert in proteomics, a new field that strives to identify and characterize all expressed proteins within a specific cell. Presently, Dr. King is working to map the human islet proteome and to identify changes in protein expression patterns that occur during the development and expansion of insulin-producing pancreatic endocrine cells.
King CC, Sastri M., Chang P., Pennypacker J., Taylor SS. "The Rate of NF-kB Nuclear Translocation is Regulated by PKA and A Kinase Interacting Protein 1" PLos One 2011 (27 April 2011)
Hinton A., Afrikanova I., Wilson M., King C.C., Maurer B., Yeo G.W., Hayek A., Pasquinelli A.E. "A distinct microRNA signature for definitive endoderm derived from human embryonic stem cells." Stem Cells Development 19(6): 797-807 (June 2010)
King CC, Bouic, K, and Friedmann, T. 2009. “A Fractionation Method to Identify Qauntitative Changes in Protein Expression Mediated by IGF-1 on the Proteome of Murine C2C12 Myoblasts” Proteome Science 2009, 7:28 (11 August 2009).
Carlin AF, Chang YC, Areschoug T, Lindahl G, Hurtado-Ziola N, King CC, Varki A, Nizet V. 2009. “Group B Streptococcus Suppression of Phagocyte Functions by Protein-Mediated Engagement of Human Siglec-5.” Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec 5. J Exp Med 2009 (online early).
Schulthess, FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, Strieter RM, Oberholzer J, King CC and Maedler K. 2009. “CXCL10 is produced by human pancreatic islets in type 2 diabetes and impairs β-cell function and viability through TLR4 signaling.” Cell Metab. 2009 Feb;9(2):125-39.
King CC, Beattie GM, Lopez AD, Hayek A. 2008. “Reduction of nonhuman sialic acid levels in human embryonic stem cells cultured in feeder layer-free conditions.” Regen Med. Mar;3(2):175-80.